Neoplasms (C00-D49)

Note:
Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

In situ neoplasms (D00-D09)

Includes:
Bowen's disease
erythroplasia
grade III intraepithelial neoplasia
Queyrat's erythroplasia
D00 Carcinoma in situ of oral cavity, esophagus and stomach [+]
Excludes 1: melanoma in situ (D03.-)
D01 Carcinoma in situ of other and unspecified digestive organs [+]
Excludes 1: melanoma in situ (D03.-)
D02 Carcinoma in situ of middle ear and respiratory system [+]
Use additional code to identify:
Use additional exposure to environmental tobacco smoke (Z77.22)
Use additional exposure to tobacco smoke in the perinatal period (P96.81)
Use additional history of tobacco dependence (Z87.891)
Use additional occupational exposure to environmental tobacco smoke (Z57.31)
Use additional tobacco dependence (F17.-)
Use additional tobacco use (Z72.0)
Excludes 1: melanoma in situ (D03.-)
D03 Melanoma in situ [+]
D04 Carcinoma in situ of skin [+]
Excludes 1: erythroplasia of Queyrat (penis) NOS (D07.4)
melanoma in situ (D03.-)
D05 Carcinoma in situ of breast [+]
Excludes 1: carcinoma in situ of skin of breast (D04.5)
melanoma in situ of breast (skin) (D03.5)
Paget's disease of breast or nipple (C50.-)
Excludes 2: malignant neoplasm of breast (C50.-)
D06 Carcinoma in situ of cervix uteri [+]
Includes: cervical adenocarcinoma in situ
cervical intraepithelial glandular neoplasia
cervical intraepithelial neoplasia III [CIN III]
severe dysplasia of cervix uteri
Excludes 1: cervical intraepithelial neoplasia II [CIN II] (N87.1)
cytologic evidence of malignancy of cervix without histologic confirmation (R87.614)
high grade squamous intraepithelial lesion (HGSIL) of cervix (R87.613)
melanoma in situ of cervix (D03.5)
moderate cervical dysplasia (N87.1)
D07 Carcinoma in situ of other and unspecified genital organs [+]
Excludes 1: melanoma in situ of trunk (D03.5)
D09 Carcinoma in situ of other and unspecified sites [+]
Excludes 1: melanoma in situ (D03.-)

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